| S.T.A.L.K.E.R. 2 | Xbox | Action | To Be Announced |
| Saints Row: The Third | Xbox | Action | Q4 2011 |
| Samurai Jack: The Shadow of Aku | Xbox | Action/Adventure | Cancelled |
| Samurai Shodown V | Xbox | Fighting | 1/17/2006 |
| Samurai Warriors | Xbox | Action | 7/13/2004 |
| Savage Safari Hunt | Xbox | Action/Adventure | Cancelled |
| Savage Skies | Xbox | Action | To Be Announced |
| Scaler | Xbox | Platformer | 10/20/2004 |
| SCAR | Xbox | Racing/Driving | Q2 2005 |
| Scarface: The World is Yours | Xbox | Action | 10/6/2006 |
| Scooby-Doo! Mystery Mayhem | Xbox | Action | 3/2/2004 |
| Scooby-Doo! Night of a 100 Frights | Xbox | Platformer | 8/26/2003 |
| Scooby-Doo! Unmasked | Xbox | Action/Adventure | 9/12/2005 |
| Scrapland | Xbox | Action/Adventure | 3/7/2005 |
| Sea World: Shamu's Deep Sea Adventures | Xbox | Action/Adventure | 11/1/2005 |
| SeaBlade | Xbox | Action | 9/14/2002 |
| Second Sight | Xbox | Action/Stealth | 9/21/2004 |
| Secret Weapons Over Normandy | Xbox | Flying | 11/18/2003 |
| Sega GT 2002 | Xbox | Racing/Driving | 9/2/2002 |
| Sega GT Online | Xbox | Racing/Driving | 1/27/2004 |
| Sensible Soccer | Xbox | Sports | Q1 2006 |
| Sentou Yousei Yukikaze | Xbox | Flying | To Be Announced |
| Seraphim | Xbox | Action/Adventure | Cancelled |
| Serious Sam | Xbox | First Person Shooter | 11/12/2002 |
| Serious Sam II | Xbox | First Person Shooter | 10/10/2005 |
| Sgt. Cruise | Xbox | Action | 2/3/2003 |
| Shadow of Memories | Xbox | Action/Adventure | To Be Announced |
| Shadow of the Sun | Xbox | First Person Shooter | To Be Announced |
| Shadow Ops: Red Mercury | Xbox | First Person Shooter | 6/15/2004 |
| Shadow The Hedgehog | Xbox | Platformer | 11/15/2005 |
| Shark Tale | Xbox | Action/Adventure | 9/27/2004 |
| Shattered Union | Xbox | Real Time Strategy | 10/17/2005 |
| Shayde: Monsters vs. Humans | Xbox | First Person Shooter | Cancelled |
| ShellShock: Nam '67 | Xbox | Action | 9/14/2004 |
| Shenmue 2 | Xbox | Action/RPG | 10/29/2002 |
| Shining Lore | Xbox | Other | To Be Announced |
| Showdown: Legends of Wrestling | Xbox | Fighting | 6/22/2004 |
| Shrek | Xbox | Adventure | 11/15/2001 |
| Shrek 2 | Xbox | Action/Adventure | 5/3/2004 |
| Shrek SuperSlam | Xbox | Fighting | 10/25/2005 |
| Shrek: Super Party | Xbox | Puzzle | 11/15/2002 |
| Sid Meier's Pirates! | Xbox | Action/Strategy | 7/11/2005 |
| Silent Hill 2: Restless Dreams | Xbox | Survival/Horror | Dec. 2001 |
| Silent Hill 4: The Room | Xbox | Survival/Horror | 9/7/2004 |
| Silent Scope Complete | Xbox | First Person Shooter | 2/10/2004 |
| Silent Space | Xbox | Strategy | Cancelled |
| Simpsons: Road Rage | Xbox | Racing/Driving | To Be Announced |
| Sitting Ducks | Xbox | Action | Q4 2003 |
| Slam Tennis | Xbox | Sports | To Be Announced |
| Smashing Drive | Xbox | Action | 3/19/2002 |
| Sneak King | Xbox | Action | 11/19/2006 |
| Sneakers | Xbox | Adventure | 10/1/2002 |
| Sniper Elite | Xbox | Action/Shooter | 10/18/2005 |
| SnoCross2: Featuring Blair Morgan | Xbox | Sports | 2006 |
| Snoopy vs. the Red Baron | Xbox | Flying | Cancelled |
| Snow | Xbox | Real Time Strategy | Q3 2006 |
| Soccer Slam | Xbox | Sports | 8/20/2002 |
| Solar 2 | Xbox | Action/Strategy | To Be Announced |
| Soldier of Fortune II: Double Helix | Xbox | First Person Shooter | 6/17/2003 |
| Sole Predator | Xbox | Simulation | To Be Announced |
| Sonic Heroes | Xbox | Platformer | 1/27/2004 |
| Sonic Mega Collection Plus | Xbox | Platformer | 11/2/2004 |
| Sonic Riders | Xbox | Racing/Driving | 2/21/2006 |
| Soul Calibur II | Xbox | Fighting | 8/26/2003 |
| Spartan: Total Warrior | Xbox | Action | 10/25/2005 |
| Spawn: Armageddon | Xbox | Action/Adventure | 11/11/2003 |
| Special Forces: Nemesis Strike | Xbox | Action/Shooter | 3/22/2005 |
| Speed Kings | Xbox | Racing/Driving | 5/20/2003 |
| Sphinx and the Cursed Mummy | Xbox | Action/Adventure | 11/10/2003 |
| Spider-Man 2 | Xbox | Action/Adventure | 6/29/2004 |
| Spider-Man: The Movie Game | Xbox | Action | 4/16/2002 |
| Spikeout: Battle Street | Xbox | Fighting | 3/28/2005 |
| Splashdown | Xbox | Racing/Driving | Q3 2002 |
| Splat Renegade Paintball | Xbox | Sports | 10/11/2005 |
| SpongeBob SquarePants: Battle for Bikini Bottom | Xbox | Platformer | 10/29/2003 |
| SpongeBob SquarePants: Lights, Camera, PANTS! | Xbox | Party | 10/19/2005 |
| SpongeBob Squarepants: The Movie | Xbox | Platformer | 10/27/2004 |
| Spooks | Xbox | Action | To Be Announced |
| Spy Fiction | Xbox | Action | Cancelled |
| Spy Vs. Spy | Xbox | Action | 4/6/2005 |
| SpyHunter | Xbox | Action | 3/12/2002 |
| SpyHunter 2 | Xbox | Action | 12/1/2003 |
| SpyHunter: Nowhere to Run | Xbox | Action | 9/5/2006 |
| Spyro The Dragon | Xbox | Action/Adventure | To Be Announced |
| Spyro: A Hero’s Tail | Xbox | Action/Adventure | 11/2/2004 |
| SSX 3 | Xbox | Sports | 10/14/2003 |
| SSX On Tour | Xbox | Extreme Sports | 10/11/2005 |
| SSX: Tricky | Xbox | Racing/Driving | Dec. 2001 |
| STACKED with Daniel Negreanu | Xbox | Card/Casino | 5/30/2006 |
| Stake: Fortune Fighters | Xbox | Fighting | 4/30/2003 |
| Stalingrad | Xbox | First Person Shooter | Cancelled |
| Star Trek: Shattered Universe | Xbox | Shooter | 1/13/2004 |
| Star Wars Battlefront II | Xbox | Action/Shooter | 10/31/2005 |
| Star Wars Galaxies | Xbox | MMO | Cancelled |
| Star Wars Jedi Knight II | Xbox | Action/Adventure | 11/1/2002 |
| Star Wars Jedi Starfighter | Xbox | Action | 5/14/2002 |
| Star Wars Starfighter: SE | Xbox | Shooter | Q4 2001 |
| Star Wars: Battlefront | Xbox | Action/Shooter | 9/20/2004 |
| Star Wars: Episode III Revenge of the Sith | Xbox | Action/Adventure | 5/5/2005 |
| Star Wars: Knights of the Old Republic | Xbox | RPG | 7/15/2003 |
| Star Wars: Knights of the Old Republic II | Xbox | RPG | 12/6/2004 |
| Star Wars: Obi-Wan | Xbox | Action | Q4 2001 |
| Star Wars: Republic Commando | Xbox | First Person Shooter | 3/1/2005 |
| Star Wars: The Clone Wars | Xbox | Action | 4/22/2003 |
| StarCraft: Ghost | Xbox | Action/Stealth | Q4 2006 |
| Stargate SG-1: The Alliance | Xbox | Action | Cancelled |
| Starsky & Hutch | Xbox | Action/Adventure | 9/9/2003 |
| State of Emergency | Xbox | Action | 3/25/2003 |
| Steel Battalion: Line of Contact | Xbox | Action | 2/27/2004 |
| Steel Battalion | Xbox | Action | 11/19/2002 |
| Still Life | Xbox | Adventure | 6/5/2005 |
| Stolen | Xbox | Action/Stealth | 4/19/2005 |
| Street Fighter Anniversary Collection | Xbox | Fighting | 2/22/2005 |
| Street Hoops | Xbox | Sports | 8/13/2002 |
| Street Racing Syndicate | Xbox | Racing/Driving | 8/31/2004 |
| Strident | Xbox | Action | Q3 2003 |
| Strike Force Bowling | Xbox | Sports | 5/4/2004 |
| Stubbs the Zombie in "Rebel without a Pulse" | Xbox | Action | 10/17/2005 |
| Stung! | Xbox | Action/Adventure | To Be Announced |
| Sudeki | Xbox | Action/RPG | 7/20/2004 |
| Super Bubble Pop | Xbox | Puzzle | 12/17/2002 |
| Super Monkey Ball Deluxe | Xbox | Platformer | 3/15/2005 |
| Superman Returns | Xbox | Action | 10/20/2006 |
| Superman: The Man of Steel | Xbox | Action/Adventure | 11/12/2002 |
| Survivor | Xbox | Survival/Horror | Cancelled |
| SVC Chaos: SNK vs. Capcom | Xbox | Fighting | 10/7/2004 |
| SWAT: Global Strike Team | Xbox | First Person Shooter | 10/21/2003 |
| SX Superstar | Xbox | Extreme Sports | 6/24/2003 |
| Syberia | Xbox | Action/Adventure | 7/28/2003 |
| Syberia II | Xbox | Adventure | 10/5/2004 |